<基礎的研究発生病理>M-SHRSP心肥大におけるα_1-receptor, Ca channelの変動

概要

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We measured α_1-receptors and the voltage-dependent Ca channel in the myocardium of 6-and 10-week-old Wistar Kyoto rats (WKY) and M strain of stroke-prone spontaneously hypertensive rats (M-SHRSP) by radioligand binding assay to clarify their role in hypertensive cardiac hypertrophy. Compared to WKY, at 6 weeks of age M-SHRSP exhibited cardiac hypertrophy, and markedly elevated blood pressure. The density of α_1-receptors on the myocardial membrane was increased by 46% in 6-week-old M-SHRSP compared to WKY, but it was decreased at 10 weeks, and the density of α_1-receptors in M-SHRSP was decreased to 73% of that in WKY. Changes in phospholipase C activity in the myocardial cytosol corresponded to those in the density of α_1-receptors. On the other hand, the number of Ca channels was higher in M-SHRSP than in WKY at both 6 and 10 weeks old. Dissociation constants of α_1-receptors and Ca channels did not change in WKY and M-SHRSP. These results suggest that both α_1-receptors and Ca channels play a role in cardiac hypertrophy in the early hypertensive stage of M-SHRSP.
近畿大学の論文
1988-12-30