心房性Na利尿ペプチドによる腎細胞質aldosterone receptorの調節

概要

論文の詳細を見る
Aldosterone receptor (AR) content in rat kidney cytosol was significantly decreased by the bolus intravenous injection of rat atriopeptin III (rAP III) in Sprague-Dawley rats under anesthesia. This effect became apparent 60 min after the injection of rAP III, and B_<max> of both types of AR high affinity, low binding capacity Type I and low affinity, high binding capacity Type II) gradually decreased and reached the peak 2 hours later. After that, decreased AR content was slightly recovered and there were no remarkable changes of the dissociation constant of AR. These effects of rAP III were also obtained when a dose of over 2.5 μg rAP III/kg body weight was given. Thus plasma aldosterone concentration (PAC) showed no significant change in our experimental conditions and we also obtained similar results in the case of rats bilaterally adrenalectomized 7 days after operation. Furthermore, furosemide had no significant effect on AR both in normal and adrenalectomized rats. These results suggest that atrial natriuretic peptide (ANP) inhibits the aldosterone action through a decreased AR content in kidney cytosol probably independently of PAC.
近畿大学の論文
1987-12-30