<臨床的研究>本態性高血圧症におけるフロセミド立位負荷時のtaurine, 血漿renin, 尿kallikreinの相互関係について

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Urinary taurine and urinary kallikrein were measured before and 30 min and 120 min after furosemide injection followed by 2 hour upright standing, while blood taurine and plasma renin activity were determined before and 120 min after the test, in 5 healthy doctors and 9 patients with essential hypertension. Furosemide test decreased the excretion rate of urinary taurine all the test period, but increased urinary kallikrein during the first 30 min period. Both urinary taurine and urinary kallikrein were significantly decreased in the essential hypertensives as compared with those in the normals. The ratio of urinary taurine to urinary creatinine and that of urinary kallikrein to urinary creatinine also significantly decreased in the essential hypertensives. Urinary kallikrein was dependent on urine flow, but urinary taurine was not. There was a significant positive correlation between urinary taurine and urinary kallikrein in the normals but no significant one in the essential hypertensives through 2 hour after furosemide injection. Both in the normals and the essential hypertensives, there was a negative correlation between urinary taurine and plasma renin activity, while no relation was found between urinary kallikrein and plasma renin activity. Further, plasma renin activity, plasma aldosterone, and plasma and blood taurine were significantly increased at 120 min after furosemide injection. Thus it is concluded that the urinary excretion pattern following furosemide injection is different between taurine and kallikrein and that taurine may have a close relation to renin-angiotensin-aldosterone system.
近畿大学の論文
1986-12-30

<臨床的研究>本態性高血圧症におけるフロセミド立位負荷時のtaurine, 血漿renin, 尿kallikreinの相互関係について

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