本態性高血圧症におけるTaurine, 血漿Renin活性, 尿Kallikrein, 尿Naとの相互関係について(B 臨床的研究)

概要

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To define a role of taurine in the pathogenesis of essential hypertension, urinary taurine, urinary kallikrein, urinary sodium, plasma renin activity and blood taurine were measured in essential hypertension. Daily urinary taurine excretion was decreased significantly in essential hypertension, and it had a significantly positive correlation with blood taurine in all subjects except for essential hypertension with treatment. When the patients were divided into Group A, urinary taurine excretion was less than 500 μmol/day, and Grour B, more than 500 μmol/day. Blood taurine was significantly decreased in Group A (P<0.05) as compared with Group B. On the other hand, plasma renin activity significantly increased in Group A (p<0.05) compared with Group B. Urinary taurine and plasma renin activity had a significantly negative correlation (r=-0.498,n=22,p<0.05). Urinary taurine excretion and urinary kallikrein had a significantly positive correlation (r=0.654,n=32,p<0.01). Urinary taurine excretion had also a significantly positive correlation (r=0.382,n=29,p<0.05) with urinary sodium excretion. These findings indicate that taurine is related not only to plasma renin activity but also urinary kallikrein in essential hypertension. Taurine should be considered as one of the pathogenetic parameters of essential hypertension.
近畿大学の論文
1982-12-31