INHIBITORY OLIGODEOXYNUCLEOTIDE IMPROVES GLOMERULONEPHRITIS AND PROLONGS SURVIVAL IN MRL-lpr/lpr MICE
スポンサーリンク
概要
- 論文の詳細を見る
Inhibitory oligodeoxynucleotides (ODNs), which are capable of blocking CpG-induced inflammation, have been anticipated to be beneficial therapeutic agents for autoimmune diseases. In this study, we show that GpC ODN, which inverted the cytosine guanine sequence of CpG motif to guanine cytosine sequence, is an inhibitory ODN. The inhibitory effects of GpC ODN on CpG ODN-induced immune activation were confirmed by cytokine assay using splenocytes from lupus-prone MRL-lpr/lpr mice. In vivo, injecting MRL-lpr/lpr mice with GpC ODN did not reduce the deposition of IgG and C3 in the glomeruli, the serum level of IL-12, the serum level of rheumatoid factors and anti-ds DNA antibody, or alter the composition of IgG isotypes of anti-ds DNA antibody. However, the mice in the GpC group showed less proteinuria, significantly lower blood urea nitrogen levels (BUN) and significantly prolonged survival. Our results suggest that inhibitory ODNs, such as GpC ODN, have the potential to become a treatment for autoimmune diseases, like lupus nephritis.
- 福島医学会の論文
著者
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Hoshi Namiko
Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima
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SUZUKI Toshimitsu
Department of Chemical Engineering
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Sato Yukio
Department Of Advanced Materials Science Graduate School Of Frontier Science The University Of Tokyo
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Sugino Takashi
Department Of Basic Pathology Fukushima Medical University
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Kobayashi Hiroko
Department Of Gastroenterology And Rheumatology Fukushima Medical University School Of Medicine
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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Hoshi Nobuo
Department Of Basic Pathology Fukushima Medical University School Of Medicine
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OHIRA HIROMASA
Department of Gastroenterology and Rheumatology
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SEKINE HIDEHARU
Department of Immunology, Fukushima Medical University School of Medicine
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OHIRA HIROMASA
Departments of Internal Medicine II, Fukushima Medical University
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HOSHI NAMIKO
Department of Internal Medicine II, Fukushima Medical University School of Medicine
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SEKINE HIDEHARU
Departments of Internal Medicine II, Fukushima Medical University
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KOBAYASHI HIROKO
Departments of Internal Medicine II, Fukushima Medical University
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