ADHESION MOLECULES AND CXC CHEMOKINES IN ENDOTOXIN-INDUCED LIVER INJURY
スポンサーリンク
概要
- 論文の詳細を見る
Interactions between leukocytes and sinusoidal endothelial cells are known to be involved in the pathogenesis of acute liver injury. Various adhesion molecules and chemokines play key roles in these cell-to-cell interactions, and the expression of these adhesion molecules and the production of chemokines are regulated by inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and interferon-γ (IFN-γ). We have shown that the expression of intercellular adhesion molecule-1 (ICAM-1) on cultured rat sinusoidal endothelial cells stimulated with TNF-α increases in a dose-dependent manner. The number of neutrophils that adhered to sinusoidal endothelial cells pretreated with TNF-α also increased in a dose-dependent manner and significantly decreased upon incubation with an anti-ICAM-1 antibody. In endotoxin-induced rat liver injury, the number of neutrophils infiltrating the sinusoids increased after serum TNF-α, macrophage inflammatory protein-2 (MIP-2) and cytok ine-induced neutrophil chemoattractant (CINC) reached their peak levels. In addition, the level of ICAM-1 expression on sinusoidal endothelial cells greatly increased from 8 h after exposure to endotoxin, and these cells were adhered to neutrophils that expressed both LFA-1 and Mac-1. Moreover, lipo-prostaglandin E1 (PGE1) reduced the extent of liver injury, and also reduced the number of neutrophils that infiltrated the liver, was reduced the production of MIP-2 and CINC, but not that of TNF-α, in rats injected with endotoxin.
- 福島医学会の論文
著者
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Rai Tsuyoshi
Department of Internal Medicine II, Fukushima Medical University School of Medicine, Fukushima
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Takiguchi Junko
Department Of Internal Medicine Ii Fukushima Medical University School Of Medicine
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Sato Yukio
Department Of Advanced Materials Science Graduate School Of Frontier Science The University Of Tokyo
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Shishido Shoichiro
Department Of Internal Medicine Ii Fukushima Medical University School Of Medicine
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Abe Kazumichi
Department Of Gastroenterology And Rheumatology Fukushima Medical University School Of Medicine
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Yokokawa Junko
Department Of Gastroenterology And Rheumatology Fukushima Medical University School Of Medicine
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OHIRA HIROMASA
Department of Gastroenterology and Rheumatology
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RAI TSUYOSHI
Department of Internal Medicine II, Fukushima Medical University School of Medicine
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