EFFECTIVENESS OF INTRAGASTRIC IMMUNIZATION WITH PROTEIN AND OLIGODEOXYNUCLEOTIDES CONTAINING A CpG MOTIF FOR INDUCING A GASTROINTESTINAL MUCOSAL IMMUNE RESPONSE IN MICE
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概要
- 論文の詳細を見る
[Purpose] To investigate a new modality of mucosal vaccines, we evaluated the effectiveness of intragastric immunization for inducing a mucosal immune response in the gastrointestinal tract. [Methods] Mice were immunized with β-galactosidase (β-gal) and synthesized oligodeoxynucleotides containing a CpG motif (CpG-DNA) by intragastric injection, and the immune response was compared with those induced by 3 other immunization forms: intranasal, oral, and intradermal. [Results] Intragastric immunization with β-gal and CpG-DNA induced significant anti-β-gal fecal IgA production at 2 weeks; however, at 4 weeks the response was lacking. In contrast, intranasal immunization with β-gal and CpG-DNA induced the highest anti-β-gal fecal IgA production at 4 weeks. [Conclusion] Although intragastric immunization with protein and CpG-DNA induces a mucosal immune response in the gastrointestinal tract, intranasal immunization is the most effective to induce both mucosal and systemic immune responses. This finding may increase the possibility for developing vaccines against mucosal pathogens, especially Helicobacter pylori.
- 福島医学会の論文
著者
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Obara Katsutoshi
Department Of Endoscopy Fukushima Medical University Hospital
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Hikichi Takuto
Department Of Endoscopy Fukushima Medical University Hospital
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Sato Yukio
Department Of Advanced Materials Science Graduate School Of Frontier Science The University Of Tokyo
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Yamamoto Go
Department Of Clinical Laboratory Nishi-kobe Medical Center
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Oyama Hitoshi
Department Of Chemistry And Chemical Engineering Faculty Of Engineering Kanazawa University
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Kobayashi Hiroko
Department Of Gastroenterology And Rheumatology Fukushima Medical University School Of Medicine
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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IRISAWA ATSUSHI
Department of Gastroenterology and Rheumatology
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