EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the effects of isosorbide dinitrate (IDN) on gastric blood flow (GBF), portal venous pressure (PVP) and blood gas of rats with liver cirrhosis (LC) accompanied by portal hypertension. Thirty male Wistar rats (LC in 17 and normal in 13) were used. Before and after IDN administration, GBF, PVP and blood gas in the femoral artery and portal vein were measured. Portal blood oxygen concentration was estimated by calculating the ratio of PO2 in portal blood and that in arterial blood (PpvO2/PaO2) of each rat. The GBF in the LC rats was significantly lower than that in the normal rats. In the LC group, IDN administration significantly increased the GBF. The PpvO2/PaO2 value in the group with LC was significantly lower after IDN administration than that before IDN administration. In the investigation whether changes in PVP or Ppv/PaO2 contributed more to the change in GBF after IDN administration, a significant correlation was found between rates of change in GBF and PpvO2/PaO2 were significantly correlated (r=−0.733, p<0.05). The effect of IDN on changes in the stomach accompanying portal hypertension is mainly attributable to a decrease in preload, which suppresses inflow to the stomach, as reflected by a decrease in PpvO2/PaO2, rather than to a decrease in afterload on GBF, as reflected by a decrease in PVP.
- 福島医学会の論文
著者
-
Obara Katsutoshi
Department Of Endoscopy Fukushima Medical University Hospital
-
Saito Ayako
Department Of Cell Physiology Kyorin University School Of Medicine
-
Sakamoto Hiroaki
Department Of Biological Functions And Engineering Kyushu Instiute Of Technology
-
Kasukawa Reiji
Department Of Internal Medicine 2 Fukushima Medical University School Of Medicine
-
Takiguchi Fujio
Department Of Internal Medicine 2 Fukushima Medical University School Of Medicine
-
OHIRA HIROMASA
Department of Gastroenterology and Rheumatology
-
IRISAWA ATSUSHI
Department of Gastroenterology and Rheumatology
-
IRISAWA ATSUSHI
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
-
OBARA KATSUTOSHI
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
-
KASUKAWA REIJI
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
-
OHIRA HIROMASA
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
-
SAKAMOTO HIROAKI
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
-
SAITO AYAKO
Department of Internal Medicine II, Fukushima Medical University, School of Medicine
関連論文
- Vein of Galen Aneurysmal Malformation in a Neonate Treated by Endovascular Surgery : Case Report
- Non-traumatic Arteriovenous Fistulas of the Scalp Treated by a Combination of Embolization and Surgical Removal
- Pancreatobiliary drainage using the EUS-FNA technique : EUS-BD and EUS-PD
- EARLY DIAGNOSIS OF SMALL PANCREATIC CANCER : ROLE OF ENDOSCOPIC ULTRASONOGRAPHY
- Endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses with rapid on-site cytological evaluation by endosonographers without attendance of cytopathologists
- Hepatocellular Carcinoma Associated with Wilson's Disease
- Six cases of primary biliary cirrhosis complicated by psoriasis
- A case of merged idiopathic portal hypertension in course of mixed connective tissue disease
- Expression of human glucocorticoid receptor in lymphocytes of patients with autoimmune hepatitis
- High frequency of anti-ribosomal P antibody in patients with systemic lupus erythematosus-associated hepatitis
- The efficacy of ursodeoxycholic acid and bezafibrate combination therapy for primary biliary cirrhosis : A prospective, multicenter study
- Synovial Mononuclear Cells Consist with T Cells Which Produce High Levels of Tumor Necrosis Factorα
- Implantation of Collar-Reinforced SuMit Valve for Patient with Large Calcified Mass Obstructing the Mitral Valve Orifice
- A Case of Hepatic Angiosarcoma Supplied by Both Hepatic Artery and Portal Vein
- Protein-losing Enteropathy Exacerbated with the Appearance of Symptoms of Systemic Lupus Erythematosus
- Takayasu's Arteritis in a 69-year-old Woman
- Two Patients with Polymyositis or Dermatomyositis Complicated with Massive Pleural Effusion
- Primary Sjogren's Syndrome Complicated by Sarcoidosis
- Constructive Interference in Steady State Imaging of Moyamoya Disease
- A case of hepatic inflammatory pseudotumor with primary biliary cirrhosis
- Analysis of a Nationwide Survey on Treatment and Outcomes of Congenital Hydrocephalus in Japan
- Magnetic Resonance Imaging Findings in Primary Amyloidosis-associated Arthropathy
- Severely Calcified Intravenous Leiomyomatosis with Cardiac Extension
- Expression of immunoreactivities to 75 kDa nerve growth factor receptor, trk gene product and phosphotyrosine in granular cell tumors
- Usefulness of endoscopic ultrasound to diagnose the severity of chronic pancreatitis
- Hemolytic Uremic Syndrome Associated with Shiga Toxin Producing Eschericia coli Infection in a Healthy Adult Woman
- Anti-Calreticulin Antibodies in Patients with Inflammatory Bowel Disease
- A case of systemic lupus erythematosus complicated by pure red cell aplasia and idiopathic portal hypertension after thymectomy
- A case of idiopathic portal hypertension associated with rheumatoid arthritis
- Lipo prostaglandin E1 reduces the production of CXC chemokines in endotoxin-induced rat liver injury
- Anti-cathepsin G antibodies in the sera of patients with ulcerative colitis
- Analysis of peripheral blood mononuclear cell stimulated with pyruvate dehydrogenase complex, T-cell receptors from patients with primary biliary cirrhosis
- High serum levels of vascular endothelial growth factor in patients with human hepatocellular carcinoma
- Antithrombin III stimulates prostaglandin I_2 production by cultured rat hepatic sinusoidal endothelial cells
- Viral, fungal and mycobacterial infections in patients with systemic lupus erythematosus
- Selective expansion of large limphoblasts expressing V_β6.1-3 or 7 in synovial fluid from patients with rheumatoid arthritis
- INTERVENTIONAL ENDOSCOPIC ULTRASONOGRAPHY : APPLICATIONS FOR CANCER RELATED TREATMENT
- Clinicolaboratory characteristics of patients with primary biliary cirrhosis associated with CREST symptoms
- AN ELECTRONIC RADIAL SCANNING ECHOENDOSCOPE IS SUPERIOR TO A MECHANICAL RADIAL SCANNING ECHOENDOSCOPE IN ULTRASOUND IMAGE QUALITY FOR GASTROINTESTINAL TRACT AND PANCREATICOBILIARY LESIONS
- Electronic Spectra of Push-Pull 4-Phenylaminoazobenzene Derivatives
- 63 Sleep apnea in children with achondroplasia and other craniofacial anomalies
- Cerebral Embolism in Off-Pump Coronary Artery Bypass Grafting
- Does Patient-Prosthesis Mismatch Affect Long-term Results after Mitral Valve Replacement?
- Pulmonary Hypertension in Connective Tissue Disease
- Modulation of adhesion molecules and carbohydrate antigens on granulocytes of patients with rheumatoid arthritis treated with granulo-monocytapheresis
- Treatment of rheumatoid arthritis by granulo-monocytapheresis
- Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing
- Acute-onset sarcoidosis with polyarthralgia and hilar lymphadenopathy
- Systemic lupus erythematosus, complicated with refractory skin ulcers, treated successfully with bosentan
- Primary sclerosing cholangitis with marked eosinophilic infiltration in the liver
- Mixed Connective Tissue Disease with Severe Pulmonary Hypertension and Extensive Subcutaneous Calcification
- The Syntaxin 5 Isoforms Syx5 and Syx5L have Distinct Effects on the Processing of β-amyloid Precursor Protein
- PROSPECTIVE RANDOMIZED COMPARATIVE STUDY OF HEMODYNAMIC CHANGES BETWEEN ULTRATHIN TRANSNASAL AND CONVENTIONAL TRANSORAL ESOPHAGOGASTRODUODENOSCOPY IN PERCUTANEOUS ENDOSCOPIC GASTROSTOMY PLACEMENT WITH MODIFIED INTRODUCER METHOD UNDER SEDATION
- T-cell clonality of peripheral blood from patients with chronic hepatitis C before and after treatment with interferon α
- Risk Factors and Treatment of Deep Sternal Wound Infection after Cardiac Operation
- Endovascular Treatment of Dural Sinus Malformation With Arteriovenous Shunt in a Low Birth Weight Neonate : Case Report
- Therapy-related myelodysplastic syndrome following cyclophosphamide pulse and/or methotrexate therapy in a patient with systemic lupus erythematosus.
- Effect of Transarterial Immunoembolization as Preoperative Treatment for Hepatocellular Carcinoma
- Primary Biliary Cirrhosis Complicated by Polymyositis and Pulmonary Hypertension
- Clinical features of liver dysfunction in collagen diseases
- Lymphocyte adhesion to cultured endothelial cells is impaired in patients with systemic lupus erythematosus
- FEASIBILITY OF INTERVENTIONAL ENDOSCOPIC ULTRASOUND USING FORWARD-VIEWING AND CURVED LINEAR-ARRAY ECHOENDOSCOPE : A LITERATURE REVIEW
- ANALYSIS OF PROGNOSTIC FACTORS IN PATIENTS WITH GASTRIC VARICES AFTER ENDOSCOPIC TREATMENT
- Reversible molecular immobilization on a metal surface through electrochemical reaction
- HEMODYNAMIC MECHANISM OF ESOPHAGEAL VARICES
- ATP assay-guided chemosensitivity testing for gemcitabine with biopsy specimens obtained from unresectable pancreatic cancer using endoscopic ultrasonography-guided fine-needle aspiration
- Do Preoperative Statins Reduce Atrial Fibrillation after Coronary Artery Bypass Grafting?
- A Recovery Case of Acute-Onset Autoimmune Hepatitis Presenting as Fulminant Hepatic Ffailure, Who Received Living Donor-Liver Transplantion
- Case of Primary Biliary Cirrhosis-Autoimmune Hepatitis Overlap which Manifested after Delivery
- CLINICAL EVALUATION OF DENDRITIC CELLS VACCINATION FOR ADVANCED CANCER PATIENTS AT FUKUSHIMA MEDICAL UNIVERSITY
- Hepatocellular Carcinoma that Relapsed 54 Months after Living Donor Liver Transplantation
- Phase I trial of preoperative intratumoral injection of immature dendritic cells and OK-432 for resectable pancreatic cancer patients
- Association of the toll-like receptor 9 gene polymorphisms with behcet's disease in a Japanese population
- Clinical Features of Cirrhosis in Japanese Patients with Type I Autoimmune Hepatitis
- Utility of peppermint oil for endoscopic diagnosis of gastric tumors
- A CASE OF OVERLAP SYNDROME OF PRIMARY BILIARY CIRRHOSIS AND AUTOIMMUNE HEPATITIS WITH MARKED ELEVATION OF IgM
- Liver Dysfunction in Patients with Systemic Lupus Erythematosus
- Gastric Antral Vascular Ectasia (GAVE) Associated with Systemic Sclerosis: Relapse after Endoscopic Treatment by Argon Plasma Coagulation
- Serum L-ficolin levels in patients with systemic lupus erythematosus
- ANTI-CALRETICULIN ANTIBODIES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE
- EFFECT OF ISOSORBIDE DINITRATE ON GASTRIC BLOOD FLOW IN RATS WITH LIVER CIRRHOSIS DETERMINED BY ANALYZING GASTRIC BLOOD FLOW, PORTAL VEIN PRESSURE AND BLOOD GAS
- A CASE OF TRANSGASTRIC GALLBLADDER PUNCTURE AS A COMPLICATION DURING ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE OF A PANCREATIC PSEUDOCYST
- APPEARANCE OF RECTAL VARICES IN EXTRAHEPATIC PORTAL OBSTRUCTION AFTER TREATMENT FOR ESOPHAGO-GASTRIC VARICES : A CASE REPORT
- TWO CASES OF PANCREATIC ABSCESS ASSOCIATED WITH PENETRATION TO THE GASTROINTESTINAL TRACT DURING TREATMENT USING ENDOSCOPIC ULTRASOUND-GUIDED DRAINAGE
- A CASE OF ESOPHAGEAL SMALL CELL CARCINOMA ASSOCIATED WITH HYPERCALCEMIA CAUSING SEVERE ACUTE PANCREATITIS
- A CASE OF RAPIDLY EXPANDING AND INCREASING FOCAL NODULAR HYPERPLASIA
- A CASE OF HEPATIC ANGIOSARCOMA SUPPLIED BY BOTH HEPATIC ARTERY AND PORTAL VEIN
- USEFULNESS OF INTRAOPERATIVE ESOPHAGOGASTRO-DUODENOSCOPY IN A PATIENT WITH LUPUS ENTERITIS
- USEFULNESS OF COMPLEMENT SPLIT PRODUCT, Bb, AS A CLINICAL MARKER FOR DISEASE ACTIVITY OF LUPUS NEPHRITIS
- USEFULNESS OF ENDOSCOPIC ULTRASONOGRAPHIC ANALYSIS OF VARICEAL HEMODYNAMICS FOR THE TREATMENT OF ESOPHAGEAL VARICES
- ATYPICAL COGAN'S SYNDROME SUCCESSFULLY TREATED WITH CORTICOSTEROIDS AND PULSE CYCLOPHOSPHAMIDE THERAPY
- INHIBITORY OLIGODEOXYNUCLEOTIDE IMPROVES GLOMERULONEPHRITIS AND PROLONGS SURVIVAL IN MRL-lpr/lpr MICE
- HLA-A2-RESTRICTED CYTOTOXIC T LYMPHOCYTE ACTIVITY DURING INTERFERON BETA THERAPY IN PATIENTS WITH CHRONIC HEPATITIS C
- ADHESION MOLECULES AND CXC CHEMOKINES IN ENDOTOXIN-INDUCED LIVER INJURY
- EFFECTIVENESS OF INTRAGASTRIC IMMUNIZATION WITH PROTEIN AND OLIGODEOXYNUCLEOTIDES CONTAINING A CpG MOTIF FOR INDUCING A GASTROINTESTINAL MUCOSAL IMMUNE RESPONSE IN MICE
- CLINICOLABORATORY CHARACTERISTICS OF JAPANESE PATIENTS WITH PRIMARY BILIARY CIRRHOSIS-AUTOIMMUNE HEPATITIS OVERLAP
- CASE OF AN ELDERLY MAN WITH ASSOCIATED HENOCH-SCHÖNLEIN PURPURA DURING TREATMENT OF ACUTE PANCREATITIS
- POSSIBLE ASSOCIATION OF CYTOTOXIC T LYMPHOCYTE ANTIGEN-4 GENETIC POLYMORPHISM WITH LIVER DAMAGE OF PRIMARY BILIARY CIRRHOSIS IN JAPAN
- Efficacy of the Extracorporeal Granulotrap G-1 Column in a Rabbit Model of Induced Arthritis(Workshop1-12)