肝動脈化学塞栓療法時の予防的抗生剤投与に関する検討―経口剤と注射剤の比較―

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Aim/background: Antibiotic prophylaxis is widely used in transcatheter arterial chemoembolization (TACE) for advanced hepatocellular carcinoma (HCC). The usefulness of oral antibiotic prophylaxis in TACE has not been established. Material/methods: One hundred forty five HCC, 76 were given oral levofloxacin (LVFX) (PO group) and 69 were administrated with cefotiam (CTM) by intravenous infusion as a historical control (DIV group), were enrolled. We investigated the clinical course and backgrounds of both groups, retrospectively. Results: There are no significant differences in clinical backgrounds, periods of hospitalization and administrating antibiotic drugs between both groups. The cost of antibiotic drugs were significant lower in PO than DIV group (3277.1 vs. 11924.4 yen, P<0.01). Conclusion: Oral LVFX was useful and a low cost medication for preventing infection after TACE.
一般社団法人　日本肝臓学会の論文