Ruthenium catalyzed reduction of nitroarenes and azaaromatic compounds using formic acid.

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概要

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• Various nitroarenes having chloro, methyl, or methoxy substituents were reduced to the corresponding aminoarenes in high yields using formic acid in the presence of a catalytic amount of RuCl<SUB>2</SUB>(PPh<SUB>3</SUB>)<SUB>3</SUB>. For example, 4-chloronitrobenzene was converted in 99% conversion with 98% selectivity at 125 °C for 5 h. 4-Nitroacetophenone was reduced chemoselectively to 1-(4-nitrophenyl)ethanol in 74% isolated yield under the same reaction conditions. Formic acid could also be employed as reductant for hydrogenation of heterocyclic compounds such as quinoline, indole, and quinoxaline in the presence of the ruthenium catalyst. 2-Methylquinoline was hydrogenated to 1,2,3,4-tetrahydro-2-methylquinoline in 93% conversion with 100% selectivity.

• 公益社団法人 日本化学会の論文

著者

• Ohta Tetsuo

  Department Of Biomedical Information Doshisha University

• Tsuji Yasushi

  Department Of Energy And Hydrocarbon Chemistry Graduate School Of Engineering Kyoto University

• Watanabe Yoshihisa

  Department Of Basic Geriatrics Graduate School Of Medical Science Kyoto Prefectural University Of Medicine

• Hiyoshi Takao

  Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University

• Tsuji Yasuo

  Department of Hydrocarbon Chemistry, Faculty of Engineering, Kyoto University

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