A Multicenter Study on the Prevalence of Eosinophilic Esophagitis and PPI-Responsive Esophageal Eosinophilic Infiltration
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概要
- 論文の詳細を見る
Objective Eosinophilic esophagitis (EoE) is diagnosed by the presence of dysphagia and intraepithelial eosinophilic infiltration of ≥15 per high-power field (HPF). EoE should be distinguished from proton pump inhibitor-responsive esophageal eosinophilic infiltration (PPI-R EEI) in patients that are responsive to PPI treatment. The aim of this study was to determine the prevalence of EoE and PPI-R EEI in Japanese patients in a multicenter study. Methods Ten hospitals participated in this study. Esophageal biopsy was performed when the patients had typical EoE symptoms or when endoscopic findings revealed a typical EoE appearance. EEI was defined as the intraepithelial eosinophilic infiltration of ≥15 per HPF. Patients with EEI received rabeprazole for 8 weeks to distinguish EoE from PPI-R EEI. Results A total of 13,634 subjects that underwent upper gastrointestinal endoscopy because of further examination or as a routine checkup were enrolled. Seventy-one (0.5%) patients suspected with EoE were examined by biopsy. A histological examination of 7 (9.9%) cases revealed EEI. Two of these 7 patients showed no symptoms and the other 5 were treated with PPI. Two (0.01%) patients were diagnosed with EoE and 3 (0.02%) with PPI-R EEI. Conclusion EoE and PPI-R EEI were rare in Japanese patients that underwent upper gastrointestinal endoscopy.
著者
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Tominaga Kazunari
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Tanigawa Tetsuya
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Takaishi Osamu
Department Of Biosignal Analysis Osaka City University Medical School
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Arakawa Tetsuo
Department Of Gastroenterology Graduate School Of Medicine Osaka City University Medical School
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Tanaka Fumio
Department Of Internal Medicine Aoto Hospital The Jikei University School Of Medicine
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Nebiki Hiroko
Department Of Gastroenterology Osaka City General Hospital
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Oshitani Nobuhide
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Uno Hironori
Department Of Internal Medicine Osaka Socio-medical Center Hospital
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Sato Hiroshi
Department Of Anatomy And Developmental Neurobiology Institute Of Health Biosciences The University
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Hayakawa Tsuyoshi
Department of Biology, Faculty of Science, Hirosaki University
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Tatsuwaki Hiroshi
Department Of Gastroenterology Osaka City University Graduate School Of Medicine
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Watanabe Toshio
Department Of Chemistry University Of Tsukuba
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Watanabe Yoshihisa
Department Of Basic Geriatrics Graduate School Of Medical Science Kyoto Prefectural University Of Medicine
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Fujiwara Yasuhiro
Department of Breast Oncology and Medical Oncology, National Cancer Center Hospital
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Takaishi Osamu
Department of Gastroenterology, Kashiwara Municipal Hospital, Japan
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Sugawa Takashi
Department of Gastroenterology, Osaka Hospital of Japanese Seafarers Relief Association, Japan
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Okuyama Masatsugu
Department of Gastroenterology, Kashiwara Municipal Hospital, Japan
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Yamamori Kazuki
Department of Gastroenterology, Osaka Hospital of Japanese Seafarers Relief Association, Japan
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Wada Rikimon
Department of Gastroenterology, Asakayama General Hospital, Japan
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Ohtani Kenjiro
Department of Gastroenterology, Nagayoshi General Hospital, Japan
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Saeki Yoshihiko
Department of Gastroenterology, Imazato Gastrointestinal Hospital, Japan
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Tominaga Kazunari
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Japan
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Tatsuwaki Hiroshi
Department of Internal Medicine, Yamamoto Third Hospital, Japan
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