Expression Level of DNA Topoisomerase Type II Alpha Predicts Chemotherapeutic Effect in Oral Squamous Cell Carcinomas

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概要

• 論文の詳細を見る

• DNA topoisomerase type II alpha (Topo IIα) nuclear enzyme is associated with chemosensitivity, chemoresistance and cell proliferation in various neoplastic lesions. This study was performed to clarify whether the Topo IIα/Ki-67 labeling ratio (T/K ratio), which reflects Topo IIα expression level, has significant predictive value in determining response to chemotherapy in oral squamous cell carcinomas (OSCC). We retrospectively reviewed the case of 22 patients with OSCC treated with chemotherapy using a combination of cisplatin and 5-FU (CF therapy). Expression of Topo IIα and Ki-67 was examined by streptoavidin-biotin peroxidase using pretreatment biopsy specimens. A significant difference in the mean T/K ratio of the effective group and the ineffective group (P<0.005) was observed. Similar findings were found with regard to Ki-67-LI values (P<0.01). However, the difference was larger in T/K ratios than in Ki-67-LI values. No difference was observed between the chemotherapeutic effects in Topo IIα-LI. The present results suggest that T/K ratios may lead to improved prediction of the effect of CF therapy.

• 特定非営利活動法人日本臨床口腔病理学会の論文
• 2003-03-25

著者

• JINBU Yoshinori

  Department of Dentistry and Oral Surgery, Jich Medical School

• WATANABE Yoshihisa

  Department of Surgery, Division II, Kobe University School of Medicine

• Tsukinoki Keiichi

  Department of Pathology, Kanagawa Dental College

• KUSAMA Mikio

  Department of Oral Surgery, Jichi Medical School

• Watanabe Yoshihisa

  Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College

• Kusama M

  Department Of Dentistry And Oral Surgery Jichi Medical School

• Kusama Mikio

  Department Of Dentistry Oral And Maxillofacial Surgery Jichi Medical School

• Ohashi Kazuyoshi

  Clinical Medical Center International University Of Health And Welfare

• Watanabe Y

  Department Of Oral Pathology Kanagawa Dental College

• Tsukinoki K

  Department Of Maxillofacial Diagnostic Science Division Of Pathology Kanagawa Dental College

• Watanabe Yoshihisa

  Department Of Community Health Tokai University School Of Medicine

• Jinbu Y

  Jich Medical School Tochigi Jpn

• Jinbu Yoshinori

  Department Of Dentistry And Oral Surgery Jich Medical School

• Tsukinoki Keiichi

  Department Of Oral Pathology Kanagawa Dental College

• Watanabe Yoshihisa

  Department Of Basic Geriatrics Graduate School Of Medical Science Kyoto Prefectural University Of Medicine

• Kusama Mikio

  Department of Dentistry and Oral Surgery, Jichi Medical School

• Tsukinoki Keiichi

  Department of Maxillofacial Diagnostic Science, Division of Pathology, Kanagawa Dental College

• Tsukinoki Keiichi

  Department of Environmental Pathology and Research Institute of Salivary Gland Health Medicine, Kanagawa Dental College Postgraduate School

• TSUKINOKI Keiichi

  Department of Diagnostic Science Division of Pathology, Kanagawa Dental College

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