イトヒキフエダイの毒性〔英文〕

概要

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An outbreak of food poisoning with 25 patients occurred from the ingestion of a chinaman fish Glabrilutjanus nematophorus in Okinawa Island in 1974. The symptoms recorded, such as diarrhea, chill, fatigue, joint-ache and dry-ice sensation, were very close to those of ciguatera. The toxicity of the flesh recovered from the fish dealer was tested on cats and mice, in which the effects were very close to those induced by ciguatoxin. The toxic principle was partially purified by column chromatography using silicic acid and DEAE-cellulose. The toxicity was checked by a mouse test. The toxin was eluted with chloroform-metanol (9:1) from a silicic acid column. By subsequent DEAE-cellulose column chromatography, two toxic components were obtained; the one was eluted with chloroform and the other with chloroform-methanol (1:1). The major toxin eluted with chloroform-methanol (1:1) was not distinguishable from ciguatoxin by either thin layer chromatography or effects in mice, while the minor toxin eluted with chloroform was clearly different from ciguatoxin.
日本水産學會の論文