薬剤耐性菌感染に関する研究

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A study was made on the prevalence of primary drug resistance for major 3 antituberculous drugs among 1, 550 cases of pulmonary tuberculosis without any previous history o f chemotherapy observed during the period from 1958 to 1967. Cases were collected from 2 sanatoria and 3dispensaries belonging to the Japan Anti-tuberculosis Association in Tokyo. Drug sensitivity was tested indirectly on 1, 228 cases and directly on 322 cases. Another study was made on the prevalence of prima r y drug resistance on 184 cases in Okinawa. Drug sensitivity test was performed by indirect method using 1% Ogawas media on: the strains collected at The Research Institute, JATA. The size of inoculum in the ind irect method was 10-3 mg. The concentra t i on of drugs in media before inspissation was as follows: SM 20 and 200mcg/ml, PAS 1 and 10 mcg/ml, and INH 0.1, 1 and 5 mcg/ml. In the case of SM, approximatel y halfjof it was inactivated after coagulation, and the results of sensitivity tes t on SM was demonstrated finally as 10 and 100 mcg/ml respectively. Criteria of resistance were as follows: S M 10 mcg complete, 10 and 100 mcg incomplete, and 100: mcg complete resistance, PAS 1 mcg complete, 1 and 10 mcg incomplete, and 10 mcg comple te resistance, and INH 1 mcg complete, 1 and 5 mcg incomplete, 5 mcg complete resistance. The results were summarized as follows: 1. The prevalence of primary drug resist a nce was 10.80; in Tokyo (Table 1). 2. The rate of primary drug resistance in these 10 years remained almost at the same level (Table 1). 3. The p r evalence of primary drug resistance in Okinawa was 9.80, and the rate was much less than that in Tokyo during the same period (Table 2). 4. The rate of primary drug resistance to each drug is s h own in Table 3. The rate for SM was much higher in Tokyo than in Okinawa. 5. The factors influencing the preval e nce of primary drug resistance in Japan was analysed in Table 5 and 6.

薬剤耐性菌感染に関する研究

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