抗結核薬の副作用防止に関する研究 : 特にPantethineの効果について

概要

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The purpose of this study is to evaluate the effectiveness of Pantethin for the prevention of side-effects by antituberculous drugs.<BR>Pulmonary tuberculous patients who have never been treated and newly admitted to the eleven institutions, were randomely divided into two groups, consisting of P-group (given daily Pantethine 3g orally) and K-group (control). Several examinations including the description on round formed questionnaire, liver function tests and audiometry, etc., were monthly carried out till two months from the beginning of the treatment.<BR>The results were as followed;<BR>1) The number of cases in which the values of GOT or GPT became abnormal or worsend (twice as high as the initial value and 35u and over) by antituberculous drugs in P-group (3.4%) were significantly (p<0.005) lower than those in K-group (17.0%). The rate of persons showing abnormal or worsened GOT or GPT by antituberculous drugs was studied by sex, age and treatment regimen, and it was higher in male, and those aged under 39, and cases treated with SM, INH, RFP showed clearly lower rate than that with SM, INH, PAS.<BR>2) The incidence rate of tinnitus in P-group was undoubtedly lower than that in K-group, however no significant difference was found between the both groups regarding the incidence of auditory disturbance, vertigo and numbness of perioral region after the administration of strepto mycin.
日本結核病学会の論文