INH耐性結核菌の人体に対する毒力-3-

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In the Part III, the problem of virulence of INH resistant bacilli is discussed biochemically according to the results of oxydation-reduction dye test, catalase-reaction and peroxydasereaction. For this purpose, 73 M. tuberculosis strains obtained from patient's sputa when their exacerbation were detected rontgenologically, were collected from all national sanatoria from May thru September, 1966. The investigation revealed that: 1) Dye-test failed to prove that the virulence was reduce d because the strain was high INH resistant. 2) In catalase-and peroxydase-reaction, the number of negative cases was increased as the degree of INH resistance was raised. 3) INH resistance test on 73 s t rains obtained from patients with radiographic exacerbation revealed a resistance over 5 mcg in 8.2%. A high INH resistant strain does not necessarily imply a harmless strain. In view of the above results, there is little doubt that some biological change must take place in INH resistant strains, but it was difficult to establish a relationship between their virulence, especially to human body, and resistance to INH.
一般社団法人日本結核病学会の論文