STUDY ON LATHYROGENIC EFFECT:Report II. Lathyrogenic Effect by INAH (isonicotinic acid hydrazide)

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概要

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• The following results were obtained from the experiments of lathyrogenic effect by injectingINAH to fertilized hens eggs:<BR>1) 7.5mg of INAH were injected into fertilized eggs placed in the inculator for 2 weeks, and at the 17th day the fragility was measured and dydroxyproline as well as rel. η in thelong bone extract were measured, and a remarkable collagen solubility was found.<BR>2) The collagen solubility increased as the injected INAH was increased in quantity, butwhen it was 30mg or more, the number of death cases was increased and collagen solubilitywas obscure.<BR>3) When 7.5mg of INAH were injected into eggs incubated for 5, 8 and 11 days respectively, the earlier the time of injection, the greater the number of death cases. All died when injectedat 5 days, and when injected at 11 days, only one of 10 cases breathed faintly but instantlydied when taken out of the shell. Its growth was apparently poor as compared with the control.<BR>4) Embryos damaged by the INAH injection were recovered when the period from theinjection to the examination was long.<BR>5) INAH derivatives, like INAH, had lathrogenic effect.<BR>6) Equimolar amount of INAH vitamin B6 was injected into the both ends of the egg at14 days and examined at 17 days. No death was observed in the pyridoxine group with orwithout INAH. All was dead in the pyridoxal group, irrespective of whether INAH was addedor not, and hard haemorrhage was observed.<BR>7) Pyridoxine somewhat decreased collagen solubility caused by INAH. On the other hand, pyridoxal could almost prevent the solubility, but since all cases died in this group, a furtherresearch is necessary to determine whether the time for INAH to achieve the effect was longenough or not.<BR>8) FKI hydrochloride (Furyl-2-methylketone isonicotinyl hydrazone) in high concentrationis hard to dissolve unless it is warmed. The diversity in FKI data seems to be due to theuncertain amount of FKI caused by the difficult dissolution. And examining paperchromatograph, two unknown compounds are found through sterilization, and thesecompounds may influence the data considerably.

• 一般社団法人 日本結核病学会の論文

著者

• 村田 彰

  国立療養所東京病院

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• STUDY ON LATHYROGENIC EFFECT:Report II. Lathyrogenic Effect by INAH (isonicotinic acid hydrazide)
• LATHYROGENIC EFFECT OF INH:Report I. Quantitative Determination of Hydroxyproline
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