Rifampicin耐性結核菌の毒力に関する実験的研究 (予報)
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The virulence of rifampicinresistant tubercle bacilli for guinea pig and mouse was reported.<BR>The rifampicinresistant strain was prepared by repeated cultivation of Kurono strain (freeze-dried and stored tubercle bacilli) on Dubos Tween Albumin media containing increasing concentration of rifampicin.<BR>For the evaluation of virulence in guinea pig, index of macroscopic findings, root spleen index and number of viable bacilli in spleen were used a in mouse, specific lung weight and number of viable bacilli in lung were used.<BR>The methods and results of examination were summarized as follows:<BR>Experiment : The virulence of tubercle bacilli resistant to 10 mcg rifampicin (RFP) for guinea pig and mouse.<BR>The strain resistant to 10 mcg RFP was prepared by cultivation of freeze-dried Kurono strain on Dubos media containing increasing concentration of rifampicin. The concentrations of rifampicin in Dubos media for making the rifampicin resistant strain were, (1) 0.02mcg→(2) 0.1 mcg→(3) 1mcg→ (4) 2.5 mcg→(5) 10 mcg. The same subculture in Dubos media not containing rifampicin was performed for original strain as the control strain.<BR>The vilurence of strain resistant to 10 mcg rifampicin attenuated markedly for guinea pig but not for mouse (Table 1, Figure 1 and Table 2, Figure 2).<BR>To elucidate the relationship of degree of rifampicin resistance and virulence for guinea pig, the following experiments were performed.<BR>Experiments 2 and 3: The virulence of tubercle bacilli resistant to 0. 1 and 1 mcg rifam picin for guinea pig.<BR>The strains resistant to 0.1 and 1 mcg rifampicin were made by cultivation of freeze-dried Kurono strain on Dubos media containing increasing concentration of rifampicin. The concen tration of rifampicin for making the rifampicin resistant strain were, (1) 0.01 mcg→(2) 0.02 mcg→(3) 0.04 mcg→(4) 0.05 mcg→ (5) 0.1 mcg (Inoculated for guinea pig)→(6) 0.4 mcg→(7) 1 mcg (Inoculated for guinea pig)→(8) 2.5 mcg→(9) 5 mcg(Inoculated for guinea pig) (10) 10 mcg.<BR>The virulence of strain resistant to 0.1 mcg rifampicin attenuated markedly comparing with the original strain which was performed the same number of subculture in Dubos media not containing rifampicin (Table 3, Figure 3 and 4).<BR>The strain resistant to 1 mcg rifampicin also showed the decreased virulence for guinea pig (Table 4, Figure 5 and 6).<BR>In conclusion, rifampicin-resistant tubercle bacilli showed markedly attenuated virulence for guinea pig.
- 日本結核病学会の論文
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