薬剤耐性菌感染に関する研究 : 第4編低耐性菌感染に関する実験的研究

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The results of experimental studies on the infection of SM or INH low-grade-resistant tubercle bacilli were reported. The methods and results of experiments we re as follows:<BR>1. The infection of SM low-grade-resistant tubercle bacilli<BR>1) First experiment<BR>24 guinea p igs and 30 mice were infected intravenously (0.1 mg in the former and 0.01 mg in the latter) with Kurono strain grown in SM 1 mcg containing Dubos medium (SM sensitivity of bacilli is demonstrated in Table 2), and each of them were divided into three groups. i. c., in guinea pigs, treated with SM 10 mg, KM 20 mg, and the control; and in mice, treated with SM 1 mg, KM 2 mg, and the control. The treatment started at 3 weeks after inoculation and continued for 4 weeks. As shown in Table 1, SM was ineffective on the animals infected with SM low- grade-resistant tubercle bacilli. SM resistance of tubercle bacilli isolated from viscera of animals showed the increase of resistant population for 10 mcg SM (Table 2).