Clinical Study on Ambulatory Chemoterapy for Drug Resistant cases of Pulmonary Tuber culosis-Methods of Treatment for Such cases.
スポンサーリンク
概要
- 論文の詳細を見る
In the previous report, the authors made astudy on the frequency of deterioration duringambulatory chemotherapy, and found that the frequency of deterioration was higher amongcases showing complete resistance to at least oneof SM, INH and PAS than among cases showingincomplete resistance to either of these drugsor susceptible cases. In the present report, the authors evaluated the therapeutic effectof ambulant chemotherapy on 75 cases ofpulmonary tuberculosis showing complete resistance to at least one of SM, INH and PASduring the course of treatment. The level ofdrug resistance was 10γ/ml for SM, and 1γ/m l for INH and PAS. The results obtainedwere the following:<BR>1. Cases were divided into 2 groups according to the bacteriologic findings in the last 6months of observation period; namely, 28 casesconverted to negative (Group I), and 47 casesshowed continuous bacilli discharge (Group II).<BR>2. Deterioration was found in 56% duringthe course of treatment, and the rates were29% and 72%respectively in Group I andGroup<BR>3. In Group I, nearly all bacilli positivecases showed complete resistance to one of the3 drugs even from the first 6 months afterstaring chemotherapy. On the contrary, inGroup II, approximately 70% of bacilli positivecases showed complete resistance to at least oneof the 3 drugs from the second 6 months andover, and among them, approximately 40%were resistant to 2 or 3 of the 3 drugs.<BR>4. In Group II, radiological deteriorationwas most frequently found during the secondyear after starting chemotherapy.<BR>5. The common regimen of chemotherapyfound among cases showing favourable response, i. e. negative conversion of tubercle bacilli orthe increase of drug susceptibility, was thecombined use of INH-FPZA, INH+Sulfa drugsand the use of nebulizer.<BR>6. Indication of surgical treatment was evaluated on 24 cases, among them 4 were inGroup 1 and 20 were in Group II. Observingfrom the stand point of pulmonary function, 16cases (67%) were suitable for surgical treatment, and from the extent and the characterof pulmonary lesions, 12 (50%) were suitablefor surgical treatment. Thus, all together, surgical treatment was indicated for 11 cases (46%).<BR>7. Surgical treatment is the method of choicefor the above discussed cases, and in case ifit is impossible, the use of INH+PZA, INH+Sulfa drugs or nebulizer is advisable.
- 一般社団法人 日本結核病学会の論文
著者
関連論文
- 肺癌診断の現状と早期発見へのアプローチ : 診断IV
- 潜在結核感染症治療中に発生した肝機能障害
- 肺結核患者における慢性気管支炎の合併について
- 肺結核患者の療養指導に関する研究
- 外来患者における非定型抗酸菌の検出と非定型抗酸菌症の治験
- 薬剤耐性菌感染に関する研究
- A STUDY ON THE PREVALENCE OF PRIMARY DRUG RESISTANCE AMONG PULMONARY TUBERCULOUS PATIENTS OBSERVED DURING THE PERIOD FROM 1955 TO 1963:Analysis on the Factors Affecting the Prevalence Rate
- Clinical Study on Ambulatory Chemoterapy for Drug Resistant cases of Pulmonary Tuber culosis-Methods of Treatment for Such cases.
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し
- タイトル無し