Effects of a platelet activating factor(PAF) antagonist CV-3988 on the acute gastric erosions of rats by water immersion and restrained stress, and by ethanol.

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We applied a platelet activating factor (PAF) antagonist CV-3988 to the acute gastric erosions in rats caused by water immersion and restrained stress to see if PAF is concerned in the acute gastric mucosal lesions (AGML) under stress. CV-3988 inhibited the formation of hemorrhagic gastric erosions by water immersion and restrained stress in a dose-dependent manner. The inhibitory effect of CV-3988 was also elicited in rats given indomethacin under water immersion and restraint stress. CV-3988 20mg/kg inhibited the ethanol-induced gastric erosions of rats. This inhibitory effect was not detereoratd by the depletion of prostaglandins by indomethacin. Our results indicate that PAF is concerned in the formation of AGML under stress.