タイトル無し

概要

論文の詳細を見る
Experimental gastric carcinoma was developed on inbred Wistar strain rats by oral administration of N-methyl-N'-nitro-N-nitrosoguanidine, and resulting tumor was transplanted successfully into subcutane of the same strain rat until 24th generation. Alkaline phosphatase (ALP) isozyme were determined in those transplantable tumor tissues, and their enzymological and immunological charaterizations were analysed.ALP isozymes did not differed significantly until 20th generation, and were similar to those of primary tumors as previously reported (Oncodevelop Biol Med 1: 313, 1980) on out-bred rats. However, after 22nd generation, ALP zymogram from the transplantable carcinoma tissues of rat stomach showed only non-intestinal-type ALP isozyme (A-band). Therefore, it was suggested the possibility that the abnormal gene expression in ALP production, especially intestinal-type ALP isozyme (B-band), had changed during the long transplantation such as over 22nd generation, and did not inherit in transplantable tumor cells.
財団法人日本消化器病学会の論文