ALKALINE PHOSPHATASE ISOZYMES FROM TRANSPLANTABLE RAT GASTRIC CARCINOMA TISSUES INDUCED BY N-METHYL-N'-VITRO-N-NITROSOGUANIDINE

概要

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Experimental gastric carcinoma was developed on inbred Wistar strain rats by oral adoministration of N-methyl-N'-nitro-N-nitrosoguanidine, and resulting tumor was trans-planted successfully into subcutane of the same strain rat. Alkaline phosphatase (ALP) isozyme was determined in 14th, 15th and 16th generation of these transplantable tumor tissues, and its enzymological and immunological characteristics were analysed. Its specific ALP activity, sensitivity to amino acids, heat-stability, neuraminidase sensitivity, electro-phoretic mobility, zymogram and sensitivity to anti-rat intestinal ALP antibody did not differed significantly in the different generations, and were also almost the same with those of primary tumors as previously reported on out-bred rats. Therefore, abnormal gene expression in ALP production, especially in intestinal ALP, was seemed to be indifferent to the strain of rats and inherit in transplantable tumor.
財団法人日本消化器病学会の論文