肝疾患における血清胆汁酸測定の臨床的意義

概要

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Total serum bile acids estimated enzymatic fluorimetrically elevated as sensitive as GPT in the experimental B-type hepatitis in chimpanzees. Increased serum bile acids levels were found only in samples taken from the patients with hepatobiliary disease among wide varieties of diagnosis. Fasting serum bile acids (F. TBA) correlated most closcly with serum bilirubin in various liver diseases (n=174) and found to be a more sensitive and nonspecific index of hepatocellular damage and cholestasis. Oral loading of 300mg ursodeoxycholic acid increased the diagnostic value of F. TBA in 90 cases with chronic liver diseases (chronic hepatitis, fatty liver and liver cirrhosis). Liver cirrhosis was proved in 26 out of 28 cases with over 30μM in F. TBA and 31 out of 32 cases with over 70μM in M. TBA. Frequency of abnormal rate of M. TBA was the highest, 92% among 14 conventional tests in chronic liver diseases and those of F. TBA, R<SUB>15</SUB>ICG and GOT were 83%, 70% and 66% in the order. It is concluded that F·TBA and M. TBA determinations are the most sensitive test for liver function.
社団法人日本肝臓学会の論文