CLINICOPATHOLOGICAL STUDY OF PRIMARY HEPATOCELLULAR CARCINOMA IN RELATION TO LIVER CIRRHOSIS AND HBsAg

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A clinicopathological study was performed in 59 patients with primary hepatocellular carcinoma in relation to liver cirrhosis and HBsAg.The incidence of HBsAg in patients with liver cirrhosis was 30% in serum and 46% in tissue. In contrast, it was negative in both serum and tissue in those without liver cirrhosis. The patients with positive HBsAg were much younger on an average age at the time of diagnosis than those with negative HBsAg. Besides, there was a significant difference in family history, clinical manifestations, liver function tests, survival time, causes of death and autopsied findings between in patients with liver cirrhosis and in those without that. This difference seemed attributable to the presence of liver cirrhosis.These results suggest that HB virus is not an associated factor with hepatocellular carcinoma in liver without liver cirrhosis, but that it might play a role on the development of hepatocellular carcinoma in combination with liver cirrhosis.
財団法人日本消化器病学会の論文