:With Special Reference to the Distribution in Normal Controls and the Patients with Peptic Ulcer

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Group II pepsinogen (PG II) levels in human serum were evaluated by human PG II radioimmunoassay system as previously reported, and analysed by decades. The cases were diagnosed endoscopically and included 265 normal controls, 259 patients with peptic ulcers (138 duodenal ulcers, 88 gastric ulcers and 33 gastroduodenal ulcers), and 106 other various disorders. Normal PG II level (mean+S.D.) was 14.1±11.1 (μg/l) without sex difference. It got higher gradually until the 6th decade (22.1±13.5), and declined thereafter until the 8th decade (8.6+7.5). The PG II levels of the patients with gastric ulcer and duodenal ulcer were 19.8±29.1 and 17.8±10.4, respectively, and they were significantly higher than those of normal controls in each decade except for 6th decade. The PG II levels of the patients with chronic renal failure showed significantly higher values (49.5±39.5) than those of normal controls and unchanged by the hemodialysis.From these results, each PG II level should be evaluated with reference to the age of the subject, and it was suggested that the possibility of the serological screening of the high-risk group in the patients with peptic ulcer.
財団法人日本消化器病学会の論文