Healing of gastric ulceration in rats, especially regenerative capacity of differentiated cells

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In order to know the regenerative pattern of gastric ulceration, the following investigations were carried out.The experimental gastric ulcer composed with the normal mucosa on the one side, and with the bases of glands on the other, was made. Regeneration of both sides were histologically compared.At the margins composed with the bases of glands, differentiated cells transformed into undifferentiated cells two days after. The cells changed into undifferentiated foveolar cells 5 days after, and differentiated to matured foveolae 14 days after. At the margins composed with normal mucosa, regenerative cells in the deep part of the newly developed epithelium were closely resembled to the regenerative cells at the margins of the bases of glands. It seemed that the regenerative cells in the deep part of the newly developed epithelium were derived from differentiated cells.On the upper side of the newly developed epithelium at the normal margins, unmatured foveolae appeared 3 days after and matured foveolae developed 5 days after. The regenerative foveolae at the upper side of the newly developed epithelium seemed to be derived from foveolae or undifferentiated cells in the neck region of glands.These findings suggest that gastric mucosal defect was repaired by either differentiated cells in the bases of glands or both the differentiated cells and undifferentiated cells in the neck of glands.
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