実験喘息における気管・気管支の反応性に関する研究

概要

論文の詳細を見る
Guinea pigs were sensitized with inhalation of "Maiko", a dust from Amorphophalus Konjac, which is also offending allergen of typical allergic asthma in human beings in Japan, and after an interval of three weeks they were divided into two groups of asthmatic and non-asthmatic by means of provocative inhalation of the dust. The muscular responses to appropriate amount of corresponding antigen, acetylcholine and histamine were compared in vitro, using tracheal spirals and ileum strips from these two groups of animals. The tracheal contractions induced by the antigen and acetylcholine in asthmatic group were far more intensive than that in non-asthmatic group, but the the ileum contraction induced by the above two substances revealed no differences between these two groups. However, apparent quantitative difference in the tissue antibody between these two groups was not found even in tracheas, when the tissue antibody was estimated by comparing the intensity of muscular contraction by allergic reaction with that by acetylcholine. The tracheas were more sensitive to histamine than to acetylcholine, but ileum showed no obvious difference in the sensitivities between these two drugs. In isolated dog trachea and bronchus, significant contraction was caused by acetylcholine, but little contraction by histamine. Human bronchial chains showed definite contraction by both histamine and acetylcholine, and yet they were rather sensitive to the former than the later. From these results, the authors concluded that the sensitivity of the tissue to such chemical mediators in allergic reaction as histamine plays a very important role in the development of asthmatic attack.
日本アレルギー学会の論文
1963-07-30

実験喘息における気管・気管支の反応性に関する研究

スポンサーリンク

概要

著者

関連論文

スポンサーリンク