まぶし喘息に関する研究 : まぶし喘息の臨床的知見補遺

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Clinical and epideomiological observations of "Mabushi" Bronchial Asthma and Investigations of antigenic substance (s) were performed with the following results: 1. Incidence rate of "Mabushi" Bronchial Asthma is about 2 per 1000 of sericultural population, it corresponds to 14% of total bronchial asthmatic patients in the sericulturist. Among sericulturists, chronic respiratory disease are a little more frequent than among other agricultural populations, and this has been considered to be due to some irritating substance (s) contained in urine of the matured silk worm larvae, the offending allergen of "Mabushi" Bronchial Asthma. 2. Patients with "Mabushi" Bronchial Asthma can clinically be classified into 3 groups according to whether the disease is induced purely by the dust from "Mabushi", or by concurrent sensitization with the dust from "Mabushi" and some other allergen(s), or more strongly by other factors than the allergic one. It is considered therapeutically valuable to treat this disease according to this classification. 3. The irritating substance (s) contained in urine of the matured silk worm larvae is dialyzable against tap water, while the antigenic substance (s) in this urine can be soluted out with ammonium sulfate or detected in the fraction obtained by aceton treatment by Boatner's method. These fraction possessing antigenicity showed positive protein reaction by Lowry's method, therefore the antigenic substance (s) seems to be protein or protein coupling substance (s).
日本アレルギー学会の論文
1968-07-31

まぶし喘息に関する研究 : まぶし喘息の臨床的知見補遺

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