Regeneration of Gastric Mucosa from Differentiated Cells in Rats:Especially Regeneration of Foveolar Epithelium

概要

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This study attempted to investigate the regenerative capacity of the differentiated glandular cells in the gastric mucosa.Adult rats of Wistar strain were used. For the purpose of removing undifferentiated cells from the gastric mucosa, upper side of the fundic mucosa on greater curvature were stripped (400μ in thickness; 10mm in diameter). In order to barricade the movement of cells from the intact mucosa to "erosive areas", the surrounding mucosa of the erosive areas were completely removed, thus annular ulcers were made. At intervals of from 12 hours to 14 days, animals were killed and the lesions were investigated histologically.From 12 hours to 7 days, the annular opening ulcers were observed in all animals, and 14 days later, in half of the animals, the ulcer still remained open. In these animals, no cells from the intact mucosa were observed in the erosive areas.At 12 hours, the differentiated chief and parietal cells in the erosive areas seemed unchanged. Two days after, the differentiated cells transformed into undifferentiated cells. The undifferentiated cells spreaded to the surface of the erosion, and changed to foveolar- liked cells at 5 and 7 days. At 14 days, well differentiated foveolar epithelium appeared in the erosive areas.It is concluded that the differentiated cells of injured gastric mucosa regenerate to the foveolar epithelium.
財団法人日本消化器病学会の論文