Healing process of experimental duodenal ulcer in rat. Regeneration of intestinal epithelium from the Brunner's glands.:Regeneration of Intestinal Epithelium from the Brunner's Glands

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Generally, it is considered that the regeneration of duodenal ulcers is performed by intestinal epithelium in the margin of the ulcers, while in this study the role of the Brunner's glands in the healing process of duodenal ulcers was investigated.The Brunner's glands were exposed with operative skinning of rats' duodenal epithelium. This area was surrounded by cauterised ulcer, so that the regenerated intestinal epithelium did not reached into the Brunner's glands area. The histological changes of the isolated Brunner's glands were investigated at 2 to 28 days after operation. The Brunner's glandular cells of the outer layer flattened, covering the surface of the ulcer, then changed gradually to the high columner cells, and finally differentiated into the intestinal epithelium and goblet cells. The Brunner's glands of the inner layer also differentiated into the intestinal epithelium.From these results, it was directly evidenced that not only the intestinal epithelium in the margin of the ulcer, but also the Brunner's glands formed the intestinal epithelium in the healing process of duodenal ulcer.
財団法人日本消化器病学会の論文