3H-thymidine Autoradiographic Studies on the Human Gastric Mucosa of chronic Gastritis
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The purpose of this studies were to investigate the human chronic gastritis by 3H-thymidine autoradiography. As it was impossible to examine throughout gastric mucous membrane by ordinary in vitro incubation, the new method was attempted.This new attempt was made to incubate the tissue under a proper physical pressure during in vitro perfusion in 3H-thymidine.An incubation apparatus was devised with two parts, that is, a vessel to hold incubation fluid and pressure device. Two cylinders were used for an incubation vessel with their bottoms put together. Gastric mucous membrane was plased between the bottoms; the incubation fluid (Eagle's medium 1.8cc, calf serum 0.2cc and 3H-thymidine 20μc) was poured into one cylinder. 10-20cmHg positive pressure was given to where the incubation fluid was and 10-20cmHg negative pressure to the other part.Using this method, a full examination throughout gastric mucous membrane was possible.1) In normal gastric mucosa, 3H-thymidine labeled cells were located only in the neck region of gastric gland and presented a dotted line.2) In the gastric mucosa with superficial gastritis, many labeled cells were located in the neck region and fairly even in the foveola.3) In the atrophic-hyperplastic gastritis, the labeled cells were located mainly in the basal area with hyperplastic foveola.4) In the atrophic gastritis, the labeled cells were found in various area, and mainly in the basal area of foveola when the atrophy was severe.5) In the intestinalized gastric mucosa, the labeled cells were found only in the basal area of epithelium; this resembled the ordinary intestinal epithelium.
- 財団法人 日本消化器病学会の論文
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