ヒト体液中の異常胆汁酸とその合成

概要

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In recent years, considerable attention has been directed to the site of origin, pathways of biosynthesis, metabolism, and excretory routes of unusual bile acids in human, particulaly for patients with hepatobiliary disease and newborn infants and fetus. In addition to five common bile acids (cholic, chenodeoxycholic, deoxycholic, ursodeoxycholic, and lithocholic acids), patients with hepatobiliary disease and newborn infants and fetus excrete a number of unusual bile acids in human biological fluids (bile, serum, urine, feces, and meconium). The unusual bile acids include the stereoisomers of the common bile acids, bile acids having various functional groups at different positions or in greater number than found in the common bile acids, and “short-chain” and “long-chain” bile acids. In this review, we compiled a list of the unusual bile acids hitherto reported in literatures and give an outline of procedures for their syntheses.
社団法人日本油化学会の論文