CHROMOSOME STUDIES OF BONE MARROW CELLS FROM NORMAL AND ALLOXAN DIABETIC WISTAR RATS

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概要

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• The gross chromosomal observations of Wistar-rat bone marrow cells during variable period of severe alloxan diabetes [11 to 12 days (group A), 19 to 22 days (group B), 31 to 44 days (group C), and 93 to 101 days (group D); and over 31 days, followed by 4 to 6 days insulin treatmcnt] as well as in control rats were performed in the shortest culture to find some of the effects of diabetic environment on the somatic chromosomes.<BR>The following results were obtained:<BR>1) The normal somatic chromosomes occupy 42 in number with very rare appearance of hypomodal cell (41) and each chromosome can be classified into 3 main components, J, V and Rod (R) shape, with two subgroups (R<SUB>1</SUB> and R<SUB>2</SUB>) in the R type. The X chromosome belongs to the R<SUB>2</SUB> subgroup and the Y chromosome to the V group in the present investigation.<BR>2) Minor chromosomal alterations have been observed in the diabetic groups of C and D, such as some hypermodal cells (43 to 45), fragmentations, additional minute chromosomes and thread-like configurations of short arm. The latter chromosomal aberration is a peculiar anomaly and needs further investigation to clarify the significance. Other chromosomal changes are not considered to be specific for alloxan diabetic rats.<BR>3) The insulin treatment in diabetic rats of over one-month's (56 to 95 days) duration caused a normalization of their idiograms, showing a disappearance of hyperdiploid cells and gross anomalies in chromosomes.<BR>The above facts are likely to indicate that a diabetic environment has an influence upon the somatic chromosomes of rats, as well as give evidence of mechanisms of transmission of diabetic traits.

• 社団法人 日本内分泌学会の論文

著者

• Yamabe Hirohiko

  Department Of Palhology Faculty Of Medicine Kyoto University

• OKAMOTO K.

  Department of Polymer Science and Engineering, Kyoto Institute of Technology

• Maruyama Toshiro

  Department Of Chemical Engineering Faculty Of Engineering Kyoto University

• KAWANISHI Hidenori

  Department of Electronic Engineering, Kohgakuin University

• KAWANISHI HIDENORI

  Department of Pathology, Faculty of Medicine, Kyoto University

• MARUYAMA TOSHIRO

  Department of Pathology, Faculty of Medicine, Kyoto University

• Okamoto K.

  Department of Pathology, Faculty of Medicine, Kyoto University

• OKAMOTO Kozo

  Department of Pathology, Faculty of Medicine, Kyoto University

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