Studies on the Thyroid in Spontaneously Hypertensive Rats II. Effect of Some Experimental Proceciures on Thyroid Activity

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1. Thyroid activity in SHR remained elevated even after the difference in adrenocortical activities between SHR and control rats was eliminated by adrenalectomy with supplements of NaCl and small doses of hydrocortisone. 2. Thyroid activity in SHR remained elevated even after the administration of hexamethonium, a ganglionic blocking drug. 3. Acute cold exposure (6-8℃, 6 hours) stimulated thyroid activity in SHR but not in control rats. This phenomenon was not prevented by adrenalectomy (with NaCl and hydrocortisone supplement) or by hexamethonium administration. 4. Chronic cold exposure (2-10℃, 6-12 weeks) stimulated thyroid activity more in SHR than in control rats. 5. Emotional stress (restraint for one hour a day for two days) depressed thyroid activity in control rats but not in SHR. The response was not affected by adrenalectomy (with NaCl and hydrocortisone supplement). 6. These results (1, 2) indicate that the elevated thyroid activity in SHR is mediated by neither the adrenal cortex nor the autonomic nervous system. 7. The significance of the different effects of cold exposure and restraint on the thyroid activi-ty in SHR (3, 4, 5) is discussed.
社団法人日本循環器学会の論文
1970-07-20