Properties of Ligand-Gated Potassium Channels in Neurons of Rat Dorsolateral Septal Nucleus.
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概要
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Properties of ligand-gated K<SUP>+</SUP> channels were examined in neurons of rat dorsolateral septal nucleus (DLSN). Application of muscarine (30μM), 5-hydroxytryptamine (5-HT, 10μM), adenosine (100μM), baclofen (10μM) and norepinephrine (NE, 10μM) to DLSN neurons caused hyperpolarizing responses associated with decreased membrane resistance. Hyperpolarizations induced by muscarine increased their amplitudes at membrane potential between -70 and -50 mV. Baclofen- and NE-induced hyperpolarizations were less sensitive to voltage. The agonist-induced hyperpolarizations decrease in amplitudes and reversed at a membrane potential between -90 and -100 mV. Ba<SUP>2+</SUP> (1 mM) blocked all agonist-induced hyperpolarizations in DLSN neurons. Tetraethylammonium (TEA, 3 mM) blocked the muscarine-induced hyperpolarization but not the hyperpolarizations induced by the other agonists. Extracellular Cs<SUP>+</SUP> and glibenclamide did not block the agonist-induced hyperpolarizations. These results suggest that muscarine, 5-HT, adenosine, baclofen and NE cause the hyperpolarization by increasing the activity of Ba<SUP>2+</SUP>-sensitive K<SUP>+</SUP> channels, probably the GTP-binding protein (G-protein) activated inward rectifier K<SUP>+</SUP> (GIRK) channels in DLSN neurons.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Hasuo Hiroshi
Department Of Anesthesiology Nagasaki University School Of Medicine
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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Goto Masashi
Department Of Comprehensive Care And Education Tenri Hospital
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Goto Masashi
Department of Applied Chemistry, Faculty of Engineering, Nagoya University
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