Presynaptic GABAA Receptors in Vertebrate Synapses.
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概要
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The presynaptic γ-aminobutyric acid<SUB>A</SUB> (GABA<SUB>A</SUB>) receptor has long been considered as the site for 'presynaptic inhibition' of synaptic transmission in the central nervous system (CNS). However, recent reports have indicated that the activation of GABA<SUB>A</SUB> receptors depolarizes primary afferent neurons and actually facilitates the release of GABA, noradrenaline, adenosine, and luteinizing hormone (LH) in central and peripheral tissues. Isoguvacine, a GABA<SUB>A</SUB> receptor agonist, enhances substance P (SP) release in the spinal cord. GABA<SUB>B</SUB> receptor agonists, but not GABA<SUB>A</SUB> receptor agonists, produce behavioral antinociception in the spinal cord. Baclofen does not directly depolarize the postsynaptic membrane, but presynaptically inhibits the activity of dorsal horn neurons. The excitatory postsynaptic potential (EPSP) evoked by stimulation of dorsal root C-fibers is inhibited by baclofen. Baclofen and GABA inhibit SP release from the primary afferent terminals by activating GABAB receptors. The activation of GABA<SUB>B</SUB> receptors inhibits calcium currents in neurons of dorsal root ganglia (DRG). It is likely that the GABA<SUB>A</SUB> receptors act as a site for 'presynaptic facilitation' of transmitter release in the CNS.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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XI ZHENG-XIONG
Department of Physiology, Kurume University School of Medicine
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