Adenosine inhibits a GABAB receptor-mediated hyperpolarizing postsynaptic potential in neurons of rat septal nuclei.
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概要
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Intracellular recordings were made from neurons of rat dorsolateral septal nucleus (DLSN), in vitro. Adenosine and 2-chloroadenosine (1-500 μM) hyperpolarized DLSN neurons and blocked the excitatory postsynaptic potential (EPSP) and the late hyperpolarizing potential (LHP) in the presence of bicuculline. Adenosine did not depress the glutamate-induced potential. Bath-application of adenosine depressed the baclofen-induced potential in 60% of the neurons. Adenosine also inhibited the LHP in the remaining 40% of neurons, while it did not depress the baclofen-induced potential in these neurons. These results indicate that adenosine inhibits the EPSP pre-synaptically whereas it inhibits the LHP both pre- and postsynaptically in rat septal nuclei.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Hasuo Hiroshi
Department Of Anesthesiology Nagasaki University School Of Medicine
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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SHOJI SHINGO
Endocrinology and Metabolism, Kurume University School of Medicine
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GALLAGHER JOEL
Department of Pharmacology and Toxicology, University of Texas Medical Branch
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