Neurokinin A Depolarizes Neurons of Bullfrog Dorsal Root Ganglia by Suppressing K+ Conductances.
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概要
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The effect of neurokinin A (NKA) on neurons of bullfrog dorsal root ganglia (DRG) in primary culture was examined by using wholecell patch-clamp methods. Application of NKA (1 μM) depolarized the DRG neurons, resulting in spontaneous firing of action potentials. Under voltageclamp condition, NKA (3 nM-1μM) caused an inward current (I<SUB>NKA</SUB>) associated with decreased membrane conductance. The I<SUB>NKA</SUB> reversed its polarity at the equilibrium potential for K<SUP>+</SUP>. The I<SUB>NKA</SUB> was blocked by extracellular Ba<SUP>2+</SUP> (1 mM) but not by nominally 0 mM Ca<SUP>2+</SUP>, tetraethylammonium (40 mM), 4-aminopyridine (2 mM) or apamin (50 nM). Intracellular Cs<SUP>+</SUP> blocked the I<SUB>NKA·</SUB> NKA depressed a voltage-dependent on-inactivating K<SUP>+</SUP> current, the Mcurrent (I<SUB>M</SUB>), at potentials more positive than -55 mV. NKA reduced the max-imum M-conductance '(G<SUB>M</SUB>) without changing the kinetics of M-channels. NKA also depressed a voltage- and time-independent background K<SUP>+</SUP> current, I<SUB>K(B)</SUB>. It is concluded that the I<SUB>NKA</SUB> is produced by suppression of both I<SUB>M</SUB> and I<SUB>K(B)</SUB> in bullfrog primary afferent neurons.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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ISHIMATSU MASARU
Department of Endocrinology and Metabolism, Kurume University School of Medicine
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