Effects of Methylphenidate on the Inhibitory Postsynaptic Potential in Rat Locus Coeruleus Neurons.
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概要
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Effects of methylphenidate (MPH), an agent used clinically for the treatment of children presenting the attention-deficit/hyperactivity disorder (AD/HD), on synaptic transmission in the rat locus coeruleus (LC) were examined by intracellular recording methods. Bath-application of MPH (30 nM-3 μM) increased the amplitude of the inhibitory postsynaptic potential (IPSP), while it did not change the amplitude of the excitatory postsynaptic potential (EPSP). MPH increased the timetopeak and the half-decay time of the IPSP in LC neurons. MPH increased the amplitude of spontaneous IPSP: individual spontaneous IPSPs merged one into the other so as to produce regular, long-lasting waves of hyperpolarization. Clonidine (10 nM), a selective agonist for α<SUB>2</SUB>-adrenoceptors, depressed the IPSP without affecting the EPSP in LC neurons. The results suggest that MPH enhances inhibitory synaptic transmission in the rat LC by depressing the norepinephrine (NE) reuptake system.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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Kuwahata Takashi
Department Of Cardiology Nanpuh Hospital
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KUWAHATA TAKASHI
Department of Physiology, Kurume University School of Medicine
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ISHIMATSU MASARU
Department of Physiology, Kurume University School of Medicine
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KIDANI YURI
Department of Physiology, Kurume University School of Medicine
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ISHIMATSU MASARU
Department of Endocrinology and Metabolism, Kurume University School of Medicine
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