L-Arginine Enhances Heat-Induced Depression of Neuronal Activity in the Rat Hippocampal CA1 Area
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概要
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Effects of L-arginine on the heat-induced depression of the neuronal activity in the hippocampal CA1 area were investigated using optical recording techniques. An increase in the temperature of hippocampal neurons from 32°C to 38°C reversibly depressed the fast and slow components of the optical response to stimulation of the Schaffer collaterals that correspond to the presynaptic action potential and excitatory postsynaptic response, respectively. The neuronal activity recovered almost completely after cooling the hippocampal neurons back to 32°C. A temperature increase to 40°C produced irreversible depression of the neuronal activity. Pyruvate, but not lactate, in the artificial cerebrospinal fluid (ACSF) attenuated the depression of the neuronal activity induced by a temperature increase to 38°C. Bath-application of L-arginine (1 mM), a nitric oxide (NO) donor, enhanced the depression of the neuronal activity at 38°C. In the presence of L-arginine, the recovery of neuronal activity, upon return to 32°C, was incomplete. The contribution of NO to the heat-induced impairment of the neuronal activity was discussed.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Hasuo Hiroshi
Department Of Anesthesiology Nagasaki University School Of Medicine
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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HASUO Hiroshi
Department of Physiology, Kurume University School of Medicine
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TAKEYA MITSUE
Department of Physiology, Kurume University School of Medicine
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