Effects of K-7259 on Neuronal Activity and Synaptic Transmission in the Rat Dorsolateral Septal Nucleus.
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概要
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K-7259 is a dilazep dihydrochloride derivative that minimizes the damaged area from middle cerebral artery hemiocclusion in the rat (Yamauchi et al. 1992a, b). The effects of K-7259 on the electrophysiological properties of neurons in the rat dorsolateral septal nuclei (DLSN) were examined. K-7259 (100μM-3 mM) depolarized the membrane with a decrease in input resistance in 36% of the DLSN cells. K-7259 (100μM) depressed the inhibitory postsynaptic potential (IPSP) and the late hyperpolarizing potential (LHP). The magnitudes of the depressions of the IPSP and LHP with 100 μM K-7259 were 50±25% (n=5) and 52±15% (n=4), respectively. The amplitudes of the excitatory postsynaptic potentials (EPSPs) were augmented during the inhibition of the IPSP and LHP. However, a voltage-clamp analysis showed that K-7259 did not affect the isolated excitatory postsynaptic current (EPSC). The outward current produced by pressure application of γ-aminobutyric acid (GABA) to the recording cell was not inhibited by K-7259. These results indicate that K-7259 presynaptically inhibits the IPSP and LHP through a GABAergic pathway.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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Tsurusaki Masashi
Department Of Physiology Kurume University School Of Medicine
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