Mild Hypothermia Prevents Post-Traumatic Hyperactivity of Excitatory Synapses in Rat Hippocampal CA1 Pyramidal Neurons
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概要
- 論文の詳細を見る
The present experiment examined the effect of mild hypothermia (35℃) on the post-traumatic hyperactivity of rat hippocampal CA1 neurons in horizontal brain slices. One week after fluid percussion injury (FPI), the optical response evoked by stimulation of the Schaffer collaterals increased in amplitude and propagation area in hippocampal CA1 slices. FPI did not alter the fast optical response that reflected the action potential of the Schaffer collaterals but enhanced the slow component that reflected the excitatory postsynaptic response. FPI increased the slope of the input-output relation (I/O function), suggesting that FPI increases the efficacy of excitatory synaptic transmission in the hippocampal CA1 pyramidal neurons. To examine the effect of low temperature on post-traumatic hyperactivity of hippocampal CA1 neurons, mild hypothermia (35℃) was administered to rats 15 min after FPI and maintained for 1-3 h. One week after FPI, the activity of hippocampal CA1 neurons in rats with mild hypothermia appeared to be reduced as compared with those receiving FPI alone. The post-traumatic enhancement of the I/O function of the slow optical response was prevented by mild hypothermia. These results suggest that mild hypothermia applied 15 min after FPI attenuates the post-traumatic hyperactivity of excitatory synapses in rat hippocampal CA1 neurons.
- 久留米大学医学部の論文
著者
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SHIGEMORI Minoru
Department of Neurosurgery, Kurume University School of Medicine
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HASUO HIROSHI
Department of Anesthesiology, Nagasaki University School of Medicine
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Hasuo Hiroshi
久留米大学 医学部生理学
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Hasuo Hiroshi
Department Of Anesthesiology Nagasaki University School Of Medicine
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AKASU Takashi
Department of Physiology, Kurume University School of Medicine
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OOBA SATOMI
Department of Physiology, Kurume University School of Medicine
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YAMASHITA SHIN
Department of Physiology, Kurume University School of Medicine
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Yamashita Shin
Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine
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Shigemori Minoru
Department Of Neurological Surgery Kurume University Medical School
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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