The Effect of Antineoplaston, a New Antitumor Agent on Malignant Brain Tumors.
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概要
- 論文の詳細を見る
Antineoplaston (Ap), a new antitumor agent, was clinically tested for effects on malignant brain tumors. The materials were 3 cases of glioblastoma (G, B), 2 cases of anaplastic astrocytoma, 1 case of pontine glioma, 2 cases of metastatic brain tumor and 1 case of medulloblastoma. All patients underwent radiochemotherapy and surgical resection of the tumors except the cases of pontine glioma, metastatic brain tumor and anaplastic astrocytoma. For gliomas, radiochemotherapy was used with Hu-IFN-β Ap was administered at a dose of 7-10 g/day in combination with remission maintenance therapy of gliomas. Complete response was obtained in one anaplastic astrocytoma. Partial response was obtained in 2 cases, a pontine glioma and a metastatic brain tumor. No change was observed in 2 cases, an anaplastic astrocytoma and a multiple brain metastasis. Progression of the disease was observed in 4 cases, 3 glioblastomas and 1 medulloblastoma, which showed continuous increase in tumor size. The effects of Ap on malignant brain tumors were considered due to synergy, since it was administered with other drugs and acceleration of tumor cellular differentiation. Ap is useful as an approach to remission maintenance therapy for brain tumors.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Hirohata Masaru
Department Of Neurosurgery Kurume University School Of Medicine
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Shigemori Minoru
Department Of Neurological Surgery Kurume University Medical School
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Tsuda Hideaki
Department Of Anesthesiology Kurume University School Of Medicine
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Maruiwa Hikaru
Department Of Neurosurgery Kurume University School Of Medicine
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Sugita Yasuo
Department Of Neurosurgery Kurume University School Of Medicine
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HIROHATA MASARU
Departments of Neurosurgery, Surgery, Kurume University School of Medicine
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HARA HIROSH
Departments of Neurosurgery, Surgery, Kurume University School of Medicine
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SUGITA YASUO
Departments of Neurosurgery, Anesthesiology Kurume University School of Medicine
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MARUIWA HIKARU
Departments of Neurosurgery, Surgery, Kurume University School of Medicine
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SHIGEMORI MINORU
Departments of Neurosurgery, Surgery, Kurume University School of Medicine
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