Edaravone Attenuates Impairment of Synaptic Plasticity in Granule Cell Layer of the Dentate Gyrus Following Traumatic Brain Injury

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概要

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• Effects of edaravone, a free radical scavenger, on post-traumatic impairment of long-term potentiation (LTP) were examined in granule cell layers of the dentate gyrus (DG) <I>in vitro</I>. Field EPSPs (fEPSPs) evoked by stimulation of the perforant path (PP) were recorded extracellularly in the DG one week after a moderate impact applied by a fluid percussion injury (FPI) device. High frequency stimulation (HFS) of the PP caused LTP of the fEPSP-slope in slices from naïve and sham-operated rats, however, the LTP was strongly depressed in slices from FPI rats. Intraperitoneal administration of edaravone 15 min after FPI prevented the hyperactivities of DG neurons and attenuated impairment of the LTP in FPI rat dentate granular cells. In vitro application of spermine NONOate (sp-NO), a nitric oxide (NO) donor, for 30 min produced a gradual increase in the fEPSP-slope, lasting for more than 2 h. Edaravone attenuated the enhancement of the fEPSP-slope induced by sp-NO. After sp-NO treatment HFS could not produce an obvious LTP in the DG granule cell layer. Pretreatment of DG slices with edaravone prevented the sp-NO-induced impairment of LTP. These results suggest that administration of edaravone after FPI protects against post-traumatic impairment of LTP in granule cell layers of the DG, possibly by scavenging NO-related radicals.

著者

• Tokutomi Takashi

  Department Of Neurosurgery Kurume University School Of Medicine

• Hasuo Hiroshi

  Department Of Anesthesiology Nagasaki University School Of Medicine

• Yamashita Shin

  Department Of Medicine And Clinical Science Gunma University Graduate School Of Medicine

• Shigemori Minoru

  Department Of Neurological Surgery Kurume University Medical School

• Akasu Takashi

  Department Of Physiology Kurume University School Of Mediceine

• HASUO Hiroshi

  Department of Physiology, Kurume University School of Medicine

• TOKUTOMI TAKASHI

  Department of Neurosurgery, University School of Medicine

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