Effects of Milnacipran on the Inhibitory Postsynaptic Potential in Neurons of the Rat Locus Coeruleus
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概要
- 論文の詳細を見る
Effects of milnacipran (MIL), a serotonin and noradrenaline reuptake inhibitor (SNRI), on synaptic transmission were examined in the rat locus coeruleus (LC). Bath-application of MIL produced a hyperpolarization associated with a decrease in input resistance of LC neurons. The MIL-induced hyperpolarization reversed polarity near the equilibrium potential of K<SUP>+</SUP>. The MILinduced hyperpolarization was blocked by yohimbine (1μM). Clonidine, but not serotonin (5-hydroxytryptamine; 5-HT), produced a hyperpolarizing potential in LC neurons. The MIL-induced hyperpolarization reversed polarity at -114±3 mV (n=4). MIL (0.1-10μM) depressed the amplitude of the excitatory postsynaptic potential (EPSP), while it enhanced the amplitude and duration of the inhibitory postsynaptic potential (IPSP). These results suggest that MIL hyperpolarizes LC neurons and enhances the IPSP by increasing endogenous noradrenaline (NA) concentration at synapses in LC neurons.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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Kuwahata Takashi
Department Of Cardiology Nanpuh Hospital
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KUWAHATA TAKASHI
Department of Physiology, Kurume University School of Medicine Kurume University
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ISHIMATSU MASARU
Department of Physiology, Kurume University School of Medicine
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KIDANI YURI
Department of Physiology, Kurume University School of Medicine
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ISHIMATSU MASARU
Department of Endocrinology and Metabolism, Kurume University School of Medicine
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