GABAc Receptors Mediate Slow Membrane Potentials in Neurons of the Rat Major Pelvic Ganglia.
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概要
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Effects of γ-aminobutyric acid (GABA) on the neuronal membrane of the rat major pelvic ganglia (MPG) were studied using intracellular recording techniques, in vitro. Application of GABA (100 μM) to MPG neurons induced a depolarization (GABA<SUB>d</SUB>) associated with a decreased membrane input resistance and a slow hyperpolarization (s-GABA<SUB>h</SUB>) associated with an increased membrane input resistance. The GABA depolarization had two phases, a fast depolarization (f-GABA<SUB>d</SUB>) and a subsequent slow depolarization (s-GABA<SUB>d</SUB>). Bicuculline (60 μM) blocked the f-GABA<SUB>d</SUB> but not the s-GABA<SUB>d</SUB> and s-GABA<SUB>h</SUB>. Picrotoxin (100 μM) blocked all the GABA responses. Imidazole-4-acetic acid (l4AA, 100 μM), a GABA<SUB>c</SUB> receptor antagonist, depressed the s-GABA<SUB>d</SUB> and s-GABA<SUB>h</SUB>, but did not block the f-GABA<SUB>d</SUB>. Cis-4-aminocrotonic acid (CACA), a GABA<SUB>c</SUB> receptor agonist, produced a depolarization followed by a hyperpolarization in MPG neurons. l4AA (100 μM) depressed the CACA-induced responses. It was concluded that GABA<SUB>A</SUB> receptors mediate the f-GABA<SUB>d</SUB> and that GABA<SUB>c</SUB> receptors mediate the s-GABA<SUB>d</SUB> and s-GABA<SUB>h</SUB>, in neurons of the rat MPG.
- 久留米大学医学部 The Kurume Medical Journal 編集部の論文
著者
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Akasu Takashi
Department Of Physiology Kurume University School Of Mediceine
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Tsurusaki Masashi
Department Of Physiology Kurume University School Of Medicine
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TSURUSAKI MASASHI
Departments of Physiology, Kurume University School of Medicine
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MUNAKATA YOSHIKAZU
Departments of Physiology, Kurume University School of Medicine
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AKASU TAKASHI
Departments of Physiology, Kurume University School of Medicine
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