高分化肝細胞癌組織に於ける Kupffer 細胞の存在

概要

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Kupffer cells in hepatocellular carcinoma (HCC) was examined by immunohistochemical detection of lysozyme, a marker of Kupffer cells, and by electron microscopy. In 4 of 20 cases, Kupffer cells were found in the cancer nodules with similar frequency as in non-neoplastic liver tissue. Large phagosomes were observed in the cytoplasm of the Kupffer cells by electron microscopy. Kupffer cells were found only in the well-differentiated parts of HCC in which tumor cells showed a one or two-cell-layered plate-like arrangement and the sinusoidal structure was well preserved. Kupffer cells were distributed in the periphery of the nodules or throughout the nodules as a mosaic. The parts of HCC which contained Kupffer cells were compressed by the undifferentiated parts. These findings indicate that Kupffer cells are present in highly differentiated HCC.
社団法人日本肝臓学会の論文