Transmission of hepatitis B virus (HBV) from HBsAg-positive females with positive e antigen to their husbands.

概要

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We analyzed histories of acute hepatitis, serum transaminase, HBsAg, anti-HBs, anti-HBc and IgM class anti-HBc in 92 young husbands whose wives were HBeAg-positive HBV-carriers. Ten of the 92 husbands (10.9%) had the past history of acute hepatitis with transient positive serum HBsAg. Most cases of acute hepatitis had developed within 6 months after marriage. Of the 92 husbands, 4 (4.3%) were positive for HBsAg, 56 (60.9%) were positive for anti-HBs, and 32 (34.8%) were negative for both HBsAg and anti-HBs by reversed passive haemagglutination and passive haemagglutination methods. In the 32 HBs antigen- and antibody-negative husbands, anti-HBc was analyzed, and 13 of them were positive for anti-HBc. In the 4 HBsAg-positive husbands, it was considered that 2 had subclinical HBV infection and the others were healthy HBV-carriers based on serum transaminase and titers of serum anti-HBc (RIA). The rate of HBV infection increased rapidly within 2 years after the marriage.
社団法人日本肝臓学会の論文