Clinical significance of IgM class anti-HBc in the patients with HBsAg-positive chronic liver disease.

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Correlation of serum IgM class anti-HBc with other serum HBV markers and presence of HBcAg or HBV core particles in the liver was studied in 25 patients with HBsAg-positive chronic liver disease. Sera were assayed for IgM class anti-HBc by both radioimmunoassay (Dainabot) and enzymeimmunoassay (Abbott). Liver biopsies were studied for HBcAg immunocytochemically using peroxidase labeled antibody method and for core particles by electron microscopy.<BR>IgM class anti-HBc was positive in 7 patients with acute exacerbation and 2 patients with continuously high level of serum transaminase. Relationship between IgM class anti-HBc and other serum HBV markers was unclear. In liver biopsies from the patients with serum IgM class anti-HBc, HBcAg-positive hepatocytes and naked core particles in sinusoidal lumen and Disse space were detected more frequently than without serum IgM class anti-HBc. These findings suggest that in type B chronic liver disease the presence of serum IgM class anti-HBc correlates with increased production of HBcAg and release of core particles from hepatocytes.
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